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A word of caution Further analysis showed that the lowest levels occurred among participants whose symptoms were most severe, whose medical histories indicated they were resistant to previous treatments, or whose onset of the disorder occurred early in life
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125,157 Diagnostic approaches include pupillometry for objectively measuring pupil size and reactivity, pharmacological testing to assess responses to agents like pilocarpine, and dynamic pupillometry as a non-invasive biomarker for autonomic dysfunction
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